Senolytic Serum is a targeted skin-longevity treatment developed to address cellular senescence, a hallmark of aging. Senescent cells are aging or stressed cells that have stopped dividing but remain active, releasing signals that can contribute to inflammation and visible signs of aging.

At the center of the formula is fisetin, a naturally occurring flavonoid extensively investigated in longevity research for its potential senolytic activity. To help preserve its integrity within an aqueous topical system, fisetin is delivered in an encapsulated form designed to protect it from degradation and support its stability.

Encapsulated fisetin is combined with astragalus root and Magnesium Ascorbyl Phosphate (MAP), a stable vitamin C derivative, to provide antioxidant support and help maintain healthy fibroblast function, promote collagen synthesis, and extracellular matrix integrity.

By supporting a healthier cellular environment, Senolytic Serum helps improve skin resilience and recovery capacity while complementing retinoids, antioxidants, peptides, and other age-delay treatments. Over time, skin appears smoother, firmer, more even-toned, and better able to respond to environmental and age-related stress.

Encapsulated Fisetin, a Senolytic
A naturally occurring flavonoid that has been extensively investigated in longevity research for its potential senolytic activity. In this formula, fisetin is encapsulated to protect it from degradation and support its stability within the aqueous topical system.

Astragalus Root
A botanical containing astragalosides and other bioactive compounds. Included for its antioxidant and skin-supportive properties and its potential to support healthy fibroblast and extracellular matrix function.

Magnesium Ascorbyl Phosphate (MAP)
A stable, water-soluble vitamin C derivative that provides antioxidant support and supports collagen synthesis and overall skin resilience.

Water/Aqua/Eau, Vinegar, Hydroxypropyl Starch Phosphate, Dipropylene Glycol, Glyceryl Caprylate, Tocopherol Polysarcosine, Magnesium Ascorbyl Phosphate, Maltodextrin, Fisetin, Xanthophylls, Chitosan, Sodium Palmitoyl Proline, Glycerin, Propanediol, Nymphaea Alba Flower Extract, Caprylhydroxamic Acid, Phosphatidylcholine, Astragalus Membranaceus Root Powder, Lecithin, Tocopherol, Citric Acid, Alcohol Denat

1. Does Senolytic Serum replace other actives in my regimen, such as retinol or an emulsion?
No. Senolytic Serum is designed to complement, rather than replace, other Marie Veronique products. It can be used alongside retinoids, antioxidants, and emulsions, with no contraindications within a Marie Veronique regimen.

By supporting a healthier cellular environment, Senolytic Serum helps promote skin responsiveness and complements the role of other age-delay actives in your regimen. Like all of our formulas, it can be used daily or incorporated throughout the week according to what works best for your skin and routine.

2. Where does Senolytic Serum fit into my regimen?
When using a complete regimen, apply it after Tonic/Mist and before Oil. If layering multiple serums, apply Senolytic Serum first.

Recommended order of application:
Cleanse → Tonic/Mist → Serum(s) → Oil → Emulsion → Balm 

We do not recommend using Senolytic Serum immediately following an invasive or intentionally wounding procedure, such as laser resurfacing, microneedling, or other treatments that temporarily compromise the skin barrier. During the wound-healing process, senescent cells can play important physiological roles in repair and tissue remodeling.

3. Can Senolytic Serum be used morning and night? 
Yes, though we recommend prioritizing evening application, when skin naturally enters a period of repair and recovery.

During the day, focus on antioxidant support and UV protection with ingredients such as vitamins C and B3, followed by sunscreen. In the evening, Senolytic Serum supports healthy cellular function and skin recovery. It can also be layered with Senolytic Balm for a more comprehensive nighttime approach to skin longevity.